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2-Fluoro-4-(7-(quinolin-6-ylmethyl)imidazo [1,2-6] [1,2,4] triazin-2-yl)benzoic acid (14). To a 22 L reactor equipped with a overhead stirring, a thermocouple, and a nitrogen inlet was charged compound 13 (900 g, 2.37 mol), water (0.9 L), and concentrated HCl (9.1 L) at room temperature. The resulting reaction mixture was heated at 100 0 C for ...
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